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While smoking side effects on the skin dont directly darken the skin, it can lead to a dull, greyish complexion and uneven skin tone, often referred to as smokers face. This effect is primarily due to the numerous harmful chemicals in cigarette smoke that damage collagen and elastin, crucial proteins for maintaining skin elasticity and brightness

Cigarettes combustion creates over 7,000 chemicals, including 69 known carcinogens

In this work, we show that e-cig aerosols acutely induce arrhythmia, impair ventricular repolarization, and alter heart rate, supraventricular conduction, and HRV, consistent with autonomic imbalance